Parekh, Jignesh M <br/><br/>
Development of an SPE-LC-MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in human plasma to support a bioequivalence study.  [electronic resource] 

 -  Journal of pharmaceutical and biomedical analysis  Nov 2012 
 - 462-70 p.  digital 
<br/><br/> Publication Type: Journal Article; Randomized Controlled Trial 
<br/><br/><label>ISSN: </label>1873-264X 
<br/><br/><label>Standard No.: </label>10.1016/j.jpba.2012.06.027  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Adult<br/>Antihypertensive Agents--administration & dosage<br/>Area Under Curve<br/>Biotransformation<br/>Bosentan<br/>Calibration<br/>Chromatography, High Pressure Liquid--standards<br/>Chromatography, Reverse-Phase--standards<br/>Cross-Over Studies<br/>Fasting--blood<br/>Half-Life<br/>Humans<br/>Hydroxylation<br/>India<br/>Male<br/>Metabolic Clearance Rate<br/>Reference Standards<br/>Reproducibility of Results<br/>Sensitivity and Specificity<br/>Solid Phase Extraction--standards<br/>Sulfonamides--administration & dosage<br/>Tablets<br/>Tandem Mass Spectrometry--standards<br/>Therapeutic Equivalency<br/>Young Adult