TY  - GEN
AU  - Verhoest,Patrick R
AU  - Fonseca,Kari R
AU  - Hou,Xinjun
AU  - Proulx-Lafrance,Caroline
AU  - Corman,Michael
AU  - Helal,Christopher J
AU  - Claffey,Michelle M
AU  - Tuttle,Jamison B
AU  - Coffman,Karen J
AU  - Liu,Shenpinq
AU  - Nelson,Frederick
AU  - Kleiman,Robin J
AU  - Menniti,Frank S
AU  - Schmidt,Christopher J
AU  - Vanase-Frawley,Michelle
AU  - Liras,Spiros
TI  - Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders
SN  - 1520-4804
PY  - 2013///0226
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Amyloid beta-Protein Precursor
KW  - genetics
KW  - Animals
KW  - Brain
KW  - metabolism
KW  - Catalytic Domain
KW  - Cognition Disorders
KW  - drug therapy
KW  - Crystallography, X-Ray
KW  - Cyclic GMP
KW  - Dogs
KW  - Drug Design
KW  - Hippocampus
KW  - drug effects
KW  - Humans
KW  - Long-Term Potentiation
KW  - Maze Learning
KW  - Mice
KW  - Mice, Transgenic
KW  - Microsomes, Liver
KW  - Models, Molecular
KW  - Protein Conformation
KW  - Pyrazoles
KW  - chemical synthesis
KW  - Pyrimidinones
KW  - Rats
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Synapses
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm3007799
ER  -