Qin, Zhihui

Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. [electronic resource] - Journal of medicinal chemistry Aug 2012 - 6784-801 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1520-4804

10.1021/jm300353r doi


Alzheimer Disease--drug therapy
Amyloid beta-Protein Precursor--genetics
Animals
Avoidance Learning--drug effects
Biological Availability
Brain--metabolism
Click Chemistry
Cognition Disorders--drug therapy
Glucose--deficiency
Hippocampus--drug effects
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Molecular Mimicry
Mutation
Neurons--cytology
Neuroprotective Agents--chemical synthesis
Nitric Oxide--chemistry
Oxygen--metabolism
Primary Cell Culture
Prodrugs--chemical synthesis
Receptors, GABA-A--metabolism
Small Molecule Libraries
Structure-Activity Relationship
Synaptic Transmission--drug effects
Thiazoles--chemical synthesis
Tissue Distribution