Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments. [electronic resource]
- Brain research Aug 2012
- 102-17 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-6240
10.1016/j.brainres.2012.06.025 doi
Amyloid Precursor Protein Secretases--metabolism Amyloid beta-Peptides--metabolism Amyloid beta-Protein Precursor--genetics Animals Apoptosis--drug effects Carbamates--pharmacology Cathepsin D--metabolism Cell Line, Tumor Chloroquine--pharmacology Dipeptides--pharmacology Dopamine--pharmacology Dose-Response Relationship, Drug Endocytosis--drug effects Gene Expression Regulation, Neoplastic--drug effects Green Fluorescent Proteins--genetics Humans In Situ Nick-End Labeling Lysosomes--drug effects Mice Mitochondrial Membranes--drug effects Neuroblastoma--pathology Pepstatins--pharmacology Phorbol Esters--pharmacology Protease Inhibitors--pharmacology Protein Biosynthesis--drug effects Proteolysis--drug effects RNA, Small Interfering--pharmacology Transfection--methods bcl-2-Associated X Protein--metabolism