6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. [electronic resource]
- PloS one 2012
- e39664 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0039664 doi
Animals Antineoplastic Agents--administration & dosage Apoptosis--drug effects Carcinoma, Hepatocellular--enzymology Catechols--administration & dosage Cell Line, Tumor Cell Survival--drug effects Cinnamates--pharmacology Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Drug Synergism Electrophoresis, Gel, Two-Dimensional Endoplasmic Reticulum Stress--drug effects Eukaryotic Initiation Factor-2--metabolism Humans Liver Neoplasms--enzymology Mice Neoplasm Proteins--metabolism Phosphorylation--drug effects RNA, Small Interfering--metabolism Thiourea--analogs & derivatives Time Factors Transcription Factor CHOP--metabolism Unfolded Protein Response--drug effects Up-Regulation--drug effects Xenograft Model Antitumor Assays eIF-2 Kinase--metabolism