TY - GEN AU - Wennerstrand,Patricia AU - Dametto,Paolo AU - Hennig,Janosch AU - Klingstedt,Therése AU - Skoglund,Karin AU - Appell,Malin Lindqvist AU - Mårtensson,Lars-Göran TI - Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5 SN - 1520-4995 PY - 2012///1126 KW - Alleles KW - Amino Acid Sequence KW - Catalytic Domain KW - genetics KW - Enzyme Activation KW - Genetic Variation KW - Humans KW - Methyltransferases KW - chemistry KW - Molecular Sequence Data N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/bi300377d ER -