TY  - GEN
AU  - Kosugi,Tomomi
AU  - Mitchell,Dale R
AU  - Fujino,Aiko
AU  - Imai,Minoru
AU  - Kambe,Mika
AU  - Kobayashi,Shinji
AU  - Makino,Hiroaki
AU  - Matsueda,Yohei
AU  - Oue,Yasuhiro
AU  - Komatsu,Kanji
AU  - Imaizumi,Keiichiro
AU  - Sakai,Yuri
AU  - Sugiura,Satoshi
AU  - Takenouchi,Osami
AU  - Unoki,Gen
AU  - Yamakoshi,Yuko
AU  - Cunliffe,Vicky
AU  - Frearson,Julie
AU  - Gordon,Richard
AU  - Harris,C John
AU  - Kalloo-Hosein,Heidi
AU  - Le,Joelle
AU  - Patel,Gita
AU  - Simpson,Donald J
AU  - Sherborne,Brad
AU  - Thomas,Peter S
AU  - Suzuki,Naotaka
AU  - Takimoto-Kamimura,Midori
AU  - Kataoka,Ken-ichiro
TI  - Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach
SN  - 1520-4804
PY  - 2012///1105
KW  - Animals
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - chemical synthesis
KW  - Cell Line
KW  - Crystallography, X-Ray
KW  - HSP27 Heat-Shock Proteins
KW  - metabolism
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - antagonists & inhibitors
KW  - Lipopolysaccharides
KW  - pharmacology
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Models, Molecular
KW  - Phosphorylation
KW  - Protein Conformation
KW  - Protein Serine-Threonine Kinases
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Shock, Septic
KW  - Small Molecule Libraries
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Tumor Necrosis Factor-alpha
KW  - biosynthesis
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm300411k
ER  -