Kosugi, Tomomi <br/><br/>
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.  [electronic resource] 

 -  Journal of medicinal chemistry  Aug 2012 
 - 6700-15 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm300411k  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis<br/>Cell Line<br/>Crystallography, X-Ray<br/>HSP27 Heat-Shock Proteins--metabolism<br/>Humans<br/>Intracellular Signaling Peptides and Proteins--antagonists & inhibitors<br/>Lipopolysaccharides--pharmacology<br/>Male<br/>Mice<br/>Mice, Inbred C57BL<br/>Models, Molecular<br/>Phosphorylation<br/>Protein Conformation<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Pyrazoles--chemical synthesis<br/>Pyrimidines--chemical synthesis<br/>Shock, Septic--metabolism<br/>Small Molecule Libraries<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Tumor Necrosis Factor-alpha--biosynthesis