TY - GEN AU - Hayashi,Kazuhiko AU - Mori,Taeko AU - Abo,Takayuki AU - Ooshima,Kenichi AU - Hayashi,Takumi AU - Komano,Tomoko AU - Takahashi,Yutaka AU - Sakaguchi,Hitoshi AU - Takatsu,Akihiko AU - Nishiyama,Naohiro TI - Two-stage bottom-up tiered approach combining several alternatives for identification of eye irritation potential of chemicals including insoluble or volatile substances SN - 1879-3177 PY - 2013///0124 KW - Animal Testing Alternatives KW - Animals KW - Cattle KW - Cell Line KW - Cell Survival KW - drug effects KW - Chorioallantoic Membrane KW - Cornea KW - Corneal Opacity KW - chemically induced KW - Eye KW - Irritants KW - classification KW - Predictive Value of Tests KW - Reproducibility of Results KW - Research Design KW - Solubility KW - Toxicity Tests, Acute KW - methods KW - Volatile Organic Compounds KW - toxicity KW - Volatilization N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.tiv.2012.06.008 ER -