Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. [electronic resource]
- Neuroscience Sep 2012
- 214-24 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1873-7544
10.1016/j.neuroscience.2012.06.024 doi
Analgesics--therapeutic use Analysis of Variance Animals Astrocytes--drug effects Body Temperature--drug effects Calcium-Binding Proteins--metabolism Cytokines--genetics Ectodysplasins--metabolism Ganglia, Spinal--drug effects Gene Expression Regulation--drug effects Glial Fibrillary Acidic Protein--metabolism Hyperalgesia--chemically induced Lipopolysaccharides--adverse effects Male Microfilament Proteins--metabolism Microglia--drug effects Minocycline--therapeutic use Pain Measurement Pain Threshold--drug effects Physical Stimulation RNA, Messenger--metabolism Rats Rats, Sprague-Dawley Reaction Time--drug effects Seizures, Febrile--chemically induced Spinal Cord--drug effects Time Factors