Peng, Haiyan

Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. [electronic resource] - The Journal of biological chemistry Aug 2012 - 28017-26 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.383380 doi


Animals
B7-1 Antigen--biosynthesis
B7-2 Antigen--biosynthesis
Cell Differentiation--drug effects
Cells, Cultured
Dendritic Cells--cytology
Dimethyl Fumarate
Fumarates--pharmacology
Histocompatibility Antigens Class II--biosynthesis
Immunosuppressive Agents--pharmacology
Interleukin-12--immunology
Interleukin-6--immunology
MAP Kinase Signaling System--drug effects
Mice
Mitogen-Activated Protein Kinase 3--immunology
Phosphorylation--drug effects
Ribosomal Protein S6 Kinases, 90-kDa--immunology
Th1 Cells--cytology
Th17 Cells--cytology
Transcription Factor RelA--immunology