TY  - GEN
AU  - Huang,Xiangao
AU  - Di Liberto,Maurizio
AU  - Jayabalan,David
AU  - Liang,Jun
AU  - Ely,Scott
AU  - Bretz,Jamieson
AU  - Shaffer,Arthur L
AU  - Louie,Tracey
AU  - Chen,Isan
AU  - Randolph,Sophia
AU  - Hahn,William C
AU  - Staudt,Louis M
AU  - Niesvizky,Ruben
AU  - Moore,Malcolm A S
AU  - Chen-Kiang,Selina
TI  - Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4
SN  - 1528-0020
PY  - 2012///1025
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Boronic Acids
KW  - administration & dosage
KW  - Bortezomib
KW  - Cell Cycle
KW  - Cell Line, Tumor
KW  - Cyclin-Dependent Kinase 4
KW  - antagonists & inhibitors
KW  - Cyclin-Dependent Kinase 6
KW  - Cytotoxins
KW  - Down-Regulation
KW  - Drug Resistance, Neoplasm
KW  - Drug Synergism
KW  - G1 Phase Cell Cycle Checkpoints
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - Interferon Regulatory Factors
KW  - genetics
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Mice, Transgenic
KW  - Multiple Myeloma
KW  - drug therapy
KW  - Protein Kinase Inhibitors
KW  - Pyrazines
KW  - Substrate Specificity
KW  - Time Factors
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1182/blood-2012-03-415984
ER  -