Huang, Xiangao <br/><br/>
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.  [electronic resource] 

 -  Blood  Aug 2012 
 - 1095-106 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1528-0020 
<br/><br/><label>Standard No.: </label>10.1182/blood-2012-03-415984  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--drug effects<br/>Boronic Acids--administration & dosage<br/>Bortezomib<br/>Cell Cycle--drug effects<br/>Cell Line, Tumor<br/>Cyclin-Dependent Kinase 4--antagonists & inhibitors<br/>Cyclin-Dependent Kinase 6--antagonists & inhibitors<br/>Cytotoxins--administration & dosage<br/>Down-Regulation--drug effects<br/>Drug Resistance, Neoplasm--drug effects<br/>Drug Synergism<br/>G1 Phase Cell Cycle Checkpoints--drug effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Humans<br/>Interferon Regulatory Factors--genetics<br/>Mice<br/>Mice, Inbred NOD<br/>Mice, SCID<br/>Mice, Transgenic<br/>Multiple Myeloma--drug therapy<br/>Protein Kinase Inhibitors--administration & dosage<br/>Pyrazines--administration & dosage<br/>Substrate Specificity<br/>Time Factors<br/>Xenograft Model Antitumor Assays