TY - GEN AU - Neco,Patricia AU - Torrente,Angelo G AU - Mesirca,Pietro AU - Zorio,Esther AU - Liu,Nian AU - Priori,Silvia G AU - Napolitano,Carlo AU - Richard,Sylvain AU - Benitah,Jean-Pierre AU - Mangoni,Matteo E AU - Gómez,Ana María TI - Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia SN - 1524-4539 PY - 2012///1203 KW - Action Potentials KW - drug effects KW - Adrenergic beta-Agonists KW - pharmacology KW - Adult KW - Aged KW - Animals KW - Calcium KW - metabolism KW - Calcium Signaling KW - Disease Models, Animal KW - Exercise KW - Female KW - Humans KW - In Vitro Techniques KW - Isoproterenol KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Mutant Strains KW - Middle Aged KW - Mutation KW - genetics KW - Patch-Clamp Techniques KW - Ryanodine Receptor Calcium Release Channel KW - Sarcoplasmic Reticulum KW - Sinoatrial Node KW - Tachycardia, Ventricular KW - Polymorphic Catecholaminergic Ventricular Tachycardia N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1161/CIRCULATIONAHA.111.075382 ER -