The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury. [electronic resource]
- The journal of trauma and acute care surgery Sep 2012
- 654-60 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
2163-0763
10.1097/TA.0b013e31825133c0 doi
Analysis of Variance Animals Biopsy, Needle Blotting, Western Brain Edema--drug therapy Brain Injuries--drug therapy Ceftriaxone--pharmacology Cytokines--metabolism Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Enzyme-Linked Immunosorbent Assay Excitatory Amino Acid Transporter 2--genetics Immunohistochemistry Neuroprotective Agents--pharmacology Random Allocation Rats Rats, Sprague-Dawley Reference Values Survival Rate Treatment Outcome Up-Regulation beta-Lactams--pharmacology