TY  - GEN
AU  - Jiang,Xiaomo
AU  - Kinch,Lisa N
AU  - Brautigam,Chad A
AU  - Chen,Xiang
AU  - Du,Fenghe
AU  - Grishin,Nick V
AU  - Chen,Zhijian J
TI  - Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
SN  - 1097-4180
PY  - 2012///0913
KW  - Animals
KW  - Cell-Free System
KW  - DEAD Box Protein 58
KW  - DEAD-box RNA Helicases
KW  - chemistry
KW  - Encephalomyocarditis virus
KW  - genetics
KW  - Fibroblasts
KW  - metabolism
KW  - HEK293 Cells
KW  - Humans
KW  - Interferon Regulatory Factor-3
KW  - Interferon-Induced Helicase, IFIH1
KW  - Interferon-beta
KW  - biosynthesis
KW  - Mice
KW  - Multiprotein Complexes
KW  - Mutagenesis, Site-Directed
KW  - Polyubiquitin
KW  - Protein Binding
KW  - Protein Interaction Mapping
KW  - Protein Processing, Post-Translational
KW  - Protein Structure, Tertiary
KW  - RNA, Viral
KW  - Receptors, Immunologic
KW  - Recombinant Fusion Proteins
KW  - Signal Transduction
KW  - physiology
KW  - Structure-Activity Relationship
KW  - Ubiquitination
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.immuni.2012.03.022
ER  -