Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. [electronic resource]
- Immunity Jun 2012
- 959-73 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1097-4180
10.1016/j.immuni.2012.03.022 doi
Animals Cell-Free System DEAD Box Protein 58 DEAD-box RNA Helicases--chemistry Encephalomyocarditis virus--genetics Fibroblasts--metabolism HEK293 Cells--metabolism Humans Interferon Regulatory Factor-3--metabolism Interferon-Induced Helicase, IFIH1 Interferon-beta--biosynthesis Mice Multiprotein Complexes Mutagenesis, Site-Directed Polyubiquitin--metabolism Protein Binding Protein Interaction Mapping Protein Processing, Post-Translational Protein Structure, Tertiary RNA, Viral--metabolism Receptors, Immunologic Recombinant Fusion Proteins--chemistry Signal Transduction--physiology Structure-Activity Relationship Ubiquitination