TY  - GEN
AU  - Salphati,Laurent
AU  - Pang,Jodie
AU  - Plise,Emile G
AU  - Lee,Leslie B
AU  - Olivero,Alan G
AU  - Prior,Wei Wei
AU  - Sampath,Deepak
AU  - Wong,Susan
AU  - Zhang,Xiaolin
TI  - Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human
SN  - 1521-009X
PY  - 2013///0117
KW  - ATP Binding Cassette Transporter, Subfamily B
KW  - deficiency
KW  - ATP Binding Cassette Transporter, Subfamily G, Member 2
KW  - ATP-Binding Cassette Transporters
KW  - Administration, Oral
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Area Under Curve
KW  - Biological Availability
KW  - Biotransformation
KW  - Brain
KW  - metabolism
KW  - Breast Neoplasms
KW  - drug therapy
KW  - Bridged Bicyclo Compounds, Heterocyclic
KW  - Cell Membrane Permeability
KW  - Dogs
KW  - Drug Dosage Calculations
KW  - Female
KW  - Half-Life
KW  - Hepatocytes
KW  - Humans
KW  - Injections, Intravenous
KW  - Intestinal Absorption
KW  - Liver
KW  - MCF-7 Cells
KW  - Macaca fascicularis
KW  - Madin Darby Canine Kidney Cells
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Mice
KW  - Mice, Knockout
KW  - Models, Biological
KW  - Phosphatidylinositol 3-Kinase
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Pyrimidines
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptor, ErbB-2
KW  - genetics
KW  - Species Specificity
KW  - TOR Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Tissue Distribution
KW  - Transfection
KW  - Xenograft Model Antitumor Assays
KW  - ATP-Binding Cassette Sub-Family B Member 4
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.112.046052
ER  -