TY - GEN AU - Bardella,Chiara AU - Olivero,Martina AU - Lorenzato,Annalisa AU - Geuna,Massimo AU - Adam,Julie AU - O'Flaherty,Linda AU - Rustin,Pierre AU - Tomlinson,Ian AU - Pollard,Patrick J AU - Di Renzo,Maria Flavia TI - Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism SN - 1098-5549 PY - 2012///1008 KW - AMP-Activated Protein Kinases KW - deficiency KW - Animals KW - Apoptosis KW - Basic Helix-Loop-Helix Transcription Factors KW - biosynthesis KW - Cell Line KW - Fumarate Hydratase KW - Fumarates KW - metabolism KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Kidney Neoplasms KW - genetics KW - Leiomyomatosis KW - Mice KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - Neoplastic Syndromes, Hereditary KW - RNA Interference KW - RNA, Small Interfering KW - Reactive Oxygen Species KW - analysis KW - Signal Transduction KW - Skin Neoplasms KW - Tumor Suppressor Proteins KW - Uterine Neoplasms N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1128/MCB.06160-11 ER -