Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. [electronic resource]
- Molecular and cellular biology Aug 2012
- 3081-94 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1098-5549
10.1128/MCB.06160-11 doi
AMP-Activated Protein Kinases--deficiency Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors--biosynthesis Cell Line Fumarate Hydratase--deficiency Fumarates--metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit--biosynthesis Kidney Neoplasms--genetics Leiomyomatosis--genetics Mice Mitogen-Activated Protein Kinase 1--biosynthesis Mitogen-Activated Protein Kinase 3--biosynthesis Neoplastic Syndromes, Hereditary--genetics RNA Interference RNA, Small Interfering Reactive Oxygen Species--analysis Signal Transduction Skin Neoplasms Tumor Suppressor Proteins--deficiency Uterine Neoplasms