A functional comparison between the HER2(high)/HER3 and the HER2(low)/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells. [electronic resource]
- Experimental & molecular medicine Aug 2012
- 473-82 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2092-6413
10.3858/emm.2012.44.8.054 doi
Breast Neoplasms--enzymology Butadienes--pharmacology Cell Line, Tumor Dose-Response Relationship, Drug Enzyme Inhibitors--pharmacology Female Gene Expression Gene Expression Regulation, Neoplastic--drug effects Humans Lapatinib MAP Kinase Signaling System MCF-7 Cells Matrix Metalloproteinase 1--genetics Matrix Metalloproteinase 9--genetics Neuregulin-1--pharmacology Nitriles--pharmacology Phosphatidylinositol 3-Kinases--metabolism Protein Kinase Inhibitors--pharmacology Protein Multimerization Proto-Oncogene Proteins c-akt--metabolism Quinazolines--pharmacology Receptor, ErbB-2--genetics Receptor, ErbB-3--metabolism