Safina, Brian S <br/><br/>
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.  [electronic resource] 

 -  Journal of medicinal chemistry  Jun 2012 
 - 5887-900 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm3003747  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Arthritis, Rheumatoid--drug therapy<br/>Benzimidazoles--chemistry<br/>Cell Line<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 CYP3A Inhibitors<br/>Drug Discovery<br/>Enzyme Inhibitors--chemistry<br/>Humans<br/>Inhibitory Concentration 50<br/>Models, Molecular<br/>Phosphatidylinositol 3-Kinases--chemistry<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Protein Conformation<br/>Substrate Specificity<br/>Time Factors