TY  - GEN
AU  - Inoue,Makoto
AU  - Williams,Kristi L
AU  - Oliver,Timothy
AU  - Vandenabeele,Peter
AU  - Rajan,Jayant V
AU  - Miao,Edward A
AU  - Shinohara,Mari L
TI  - Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome
SN  - 1937-9145
PY  - 2012///0917
KW  - Animals
KW  - Apoptosis Regulatory Proteins
KW  - CARD Signaling Adaptor Proteins
KW  - CD4-Positive T-Lymphocytes
KW  - transplantation
KW  - Carrier Proteins
KW  - genetics
KW  - Caspase 1
KW  - physiology
KW  - Cytoskeletal Proteins
KW  - deficiency
KW  - Disease Models, Animal
KW  - Encephalomyelitis, Autoimmune, Experimental
KW  - drug therapy
KW  - Enzyme Activation
KW  - Gene Expression Regulation
KW  - drug effects
KW  - Inflammasomes
KW  - Interferon beta-1b
KW  - Interferon-beta
KW  - therapeutic use
KW  - Interleukin-1beta
KW  - biosynthesis
KW  - Macrophages
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mice, Transgenic
KW  - NLR Family, Pyrin Domain-Containing 3 Protein
KW  - Neuropeptides
KW  - antagonists & inhibitors
KW  - Proto-Oncogene Proteins c-vav
KW  - Reactive Oxygen Species
KW  - metabolism
KW  - Receptor, Interferon alpha-beta
KW  - Recombinant Proteins
KW  - Suppressor of Cytokine Signaling 1 Protein
KW  - Suppressor of Cytokine Signaling Proteins
KW  - rac GTP-Binding Proteins
KW  - rac1 GTP-Binding Protein
N1  - Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/scisignal.2002767
ER  -