The FKBP-rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator phosphatidic acid. [electronic resource]
- Biochemistry Jun 2012
- 4909-21 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4995
10.1021/bi3002133 doi
Cell Membrane--chemistry Humans Liposomes--pharmacology Micelles Models, Molecular Phosphatidic Acids--pharmacology Protein Structure, Secondary--drug effects Protein Structure, Tertiary--drug effects Sirolimus--metabolism TOR Serine-Threonine Kinases--chemistry Tacrolimus Binding Protein 1A--metabolism