Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. [electronic resource]
- Cell May 2012
- 860-70 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1097-4172
10.1016/j.cell.2012.02.063 doi
Amino Acid Sequence Crystallography, X-Ray ErbB Receptors--antagonists & inhibitors Gefitinib Humans Lapatinib Molecular Dynamics Simulation Molecular Sequence Data Neoplasms--metabolism Point Mutation Protein Folding Protein Kinase Inhibitors--pharmacology Protein Multimerization Protein Structure, Tertiary Quinazolines--pharmacology Sequence Alignment Signal Transduction