Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells. [electronic resource]
- The journal of gene medicine Jul 2012
- 445-58 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-2254
10.1002/jgm.2630 doi
Animals Apoptosis Cell Line, Tumor Cell Survival Chemotherapy, Adjuvant Cytosine Deaminase--genetics Drug Resistance, Neoplasm Drug Therapy, Combination Escherichia coli--enzymology Flucytosine--therapeutic use Genes, Transgenic, Suicide--genetics Genetic Therapy--methods Humans Lung Neoplasms--therapy Male Mice Nitroreductases--therapeutic use Pentosyltransferases--genetics Promoter Regions, Genetic--genetics Repressor Proteins--genetics Small Cell Lung Carcinoma--therapy Yeasts--enzymology