Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. [electronic resource]
- The Journal of biological chemistry Jun 2012
- 21335-45 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M112.341032 doi
Cell Line Collagenases--biosynthesis Extracellular Matrix--genetics Female Fibronectins--genetics Gene Expression Regulation, Enzymologic High-Temperature Requirement A Serine Peptidase 1 Humans Intervertebral Disc--enzymology Intervertebral Disc Degeneration--enzymology MAP Kinase Kinase 1--genetics Male Polymorphism, Single Nucleotide Proteolysis Recombinant Proteins--biosynthesis Serine Endopeptidases--biosynthesis