Hughes, Z A <br/><br/>
Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.  [electronic resource] 

 -  Neuropharmacology  Mar 2013 
 - 202-14 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1873-7064 
<br/><br/><label>Standard No.: </label>10.1016/j.neuropharm.2012.04.007  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation--drug effects<br/>Analgesics--pharmacology<br/>Animals<br/>Anti-Anxiety Agents--pharmacology<br/>Antidepressive Agents--adverse effects<br/>Behavior, Animal--drug effects<br/>Benzamides--adverse effects<br/>Calcium--metabolism<br/>Depressive Disorder, Treatment-Resistant--drug therapy<br/>Disease Models, Animal<br/>Dose-Response Relationship, Drug<br/>Drug Evaluation, Preclinical--methods<br/>Excitatory Amino Acid Antagonists--adverse effects<br/>Glutamic Acid--pharmacology<br/>HEK293 Cells<br/>Humans<br/>Mice<br/>Pyridines--adverse effects<br/>Radioligand Assay--methods<br/>Rats<br/>Receptor, Metabotropic Glutamate 5<br/>Receptors, Metabotropic Glutamate--antagonists & inhibitors