TY  - GEN
AU  - Leahy,James W
AU  - Buhr,Chris A
AU  - Johnson,Henry W B
AU  - Kim,Byung Gyu
AU  - Baik,Taegon
AU  - Cannoy,Jonah
AU  - Forsyth,Timothy P
AU  - Jeong,Joon Won
AU  - Lee,Matthew S
AU  - Ma,Sunghoon
AU  - Noson,Kevin
AU  - Wang,Longcheng
AU  - Williams,Matthew
AU  - Nuss,John M
AU  - Brooks,Eric
AU  - Foster,Paul
AU  - Goon,Leanne
AU  - Heald,Nathan
AU  - Holst,Charles
AU  - Jaeger,Christopher
AU  - Lam,Scott
AU  - Lougheed,Julie
AU  - Nguyen,Lam
AU  - Plonowski,Arthur
AU  - Song,Joanne
AU  - Stout,Thomas
AU  - Wu,Xiang
AU  - Yakes,Michael F
AU  - Yu,Peiwen
AU  - Zhang,Wentao
AU  - Lamb,Peter
AU  - Raeber,Olivia
TI  - Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors
SN  - 1520-4804
PY  - 2012///1001
KW  - Administration, Oral
KW  - Animals
KW  - Biological Availability
KW  - Cell Line
KW  - Crystallography, X-Ray
KW  - Female
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - Isoenzymes
KW  - antagonists & inhibitors
KW  - Luminescent Measurements
KW  - Mice
KW  - Microsomes, Liver
KW  - metabolism
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Phosphorylation
KW  - Piperazines
KW  - chemical synthesis
KW  - Proto-Oncogene Proteins c-akt
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Structure-Activity Relationship
KW  - Sulfonamides
KW  - Sulfones
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm300403a
ER  -