Leahy, James W <br/><br/>
Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.  [electronic resource] 

 -  Journal of medicinal chemistry  Jun 2012 
 - 5467-82 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm300403a  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Biological Availability<br/>Cell Line<br/>Crystallography, X-Ray<br/>Female<br/>High-Throughput Screening Assays<br/>Humans<br/>Isoenzymes--antagonists & inhibitors<br/>Luminescent Measurements<br/>Mice<br/>Microsomes, Liver--metabolism<br/>Models, Molecular<br/>Molecular Structure<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Phosphorylation<br/>Piperazines--chemical synthesis<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Rats<br/>Rats, Sprague-Dawley<br/>Structure-Activity Relationship<br/>Sulfonamides--chemical synthesis<br/>Sulfones--chemical synthesis