TY  - GEN
AU  - Lacey,David L
AU  - Boyle,William J
AU  - Simonet,W Scott
AU  - Kostenuik,Paul J
AU  - Dougall,William C
AU  - Sullivan,John K
AU  - San Martin,Javier
AU  - Dansey,Roger
TI  - Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab
SN  - 1474-1784
PY  - 2012///0622
KW  - Animals
KW  - Antibodies, Monoclonal
KW  - pharmacology
KW  - Antibodies, Monoclonal, Humanized
KW  - Bone Resorption
KW  - physiopathology
KW  - Bone and Bones
KW  - metabolism
KW  - Denosumab
KW  - Drug Design
KW  - Humans
KW  - Osteoclasts
KW  - physiology
KW  - Osteoprotegerin
KW  - RANK Ligand
KW  - antagonists & inhibitors
KW  - Receptor Activator of Nuclear Factor-kappa B
KW  - Signal Transduction
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
UR  - https://doi.org/10.1038/nrd3705
ER  -