Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. [electronic resource]
- Nature chemical biology Apr 2012
- 547-54 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1552-4469
10.1038/nchembio.937 doi
Animals Catalytic Domain Cell Culture Techniques Cell Nucleus--drug effects Cytoplasm--drug effects DNA-Activated Protein Kinase--genetics Electrophoresis, Polyacrylamide Gel Embryo, Nonmammalian--enzymology HeLa Cells Humans Immunoprecipitation Interferon-gamma--pharmacology Microscopy, Confocal Models, Molecular Phosphorylation Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases--genetics Protein Interaction Maps Signal Transduction--drug effects Transfection Tryptophan-tRNA Ligase--genetics Tumor Suppressor Protein p53--genetics Zebrafish--embryology