TY - GEN AU - Martínez de Lizarrondo,Sara AU - Roncal,Carmen AU - Calvayrac,Olivier AU - Rodríguez,Cristina AU - Varo,Nerea AU - Purroy,Ana AU - Lorente,Leonardo AU - Rodríguez,José A AU - Doeuvre,Loïc AU - Hervás-Stubbs,Sandra AU - Angles-Cano,Eduardo AU - Páramo,José A AU - Martínez-González,José AU - Orbe,Josune TI - Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo SN - 1524-4636 PY - 2012///0713 KW - Adult KW - Aged KW - Aged, 80 and over KW - Animals KW - Antibodies KW - pharmacology KW - Blood Coagulation KW - CD40 Antigens KW - antagonists & inhibitors KW - CD40 Ligand KW - Case-Control Studies KW - Cell-Derived Microparticles KW - enzymology KW - Cells, Cultured KW - Disease Models, Animal KW - Disseminated Intravascular Coagulation KW - Endothelial Cells KW - drug effects KW - Endotoxemia KW - Female KW - Gene Expression Regulation, Enzymologic KW - Hirudins KW - Human Umbilical Vein Endothelial Cells KW - Humans KW - Lipopolysaccharides KW - Male KW - Matrix Metalloproteinase 10 KW - blood KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Middle Aged KW - Mitogen-Activated Protein Kinase 8 KW - Multivariate Analysis KW - Peptides KW - Protein Kinase Inhibitors KW - RNA, Messenger KW - metabolism KW - Receptor, PAR-1 KW - agonists KW - Risk Assessment KW - Risk Factors KW - Sepsis KW - Signal Transduction KW - Spain KW - Survival Analysis KW - Thrombin KW - Time Factors KW - Up-Regulation KW - p38 Mitogen-Activated Protein Kinases KW - Platelet Aggregation Inhibitors N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1161/ATVBAHA.112.248773 ER -