TY - GEN AU - Gallardo,A AU - Lerma,E AU - Escuin,D AU - Tibau,A AU - Muñoz,J AU - Ojeda,B AU - Barnadas,A AU - Adrover,E AU - Sánchez-Tejada,L AU - Giner,D AU - Ortiz-Martínez,F AU - Peiró,G TI - Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas SN - 1532-1827 PY - 2012///0625 KW - Adult KW - Aged KW - Aged, 80 and over KW - Antibodies, Monoclonal, Humanized KW - pharmacology KW - Breast Neoplasms KW - diagnosis KW - Drug Resistance, Neoplasm KW - drug effects KW - ErbB Receptors KW - metabolism KW - Female KW - Humans KW - Middle Aged KW - Neoplasm Staging KW - PTEN Phosphohydrolase KW - Phosphatidylinositol 3-Kinases KW - genetics KW - Prognosis KW - Proto-Oncogene Proteins c-akt KW - Receptor, ErbB-2 KW - Receptor, IGF Type 1 KW - Signal Transduction KW - Survival Analysis KW - Trastuzumab N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/bjc.2012.85 ER -