Xu, Min-fang <br/><br/>
Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.  [electronic resource] 

 -  Acta pharmacologica Sinica  May 2012 
 - 578-87 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1745-7254 
<br/><br/><label>Standard No.: </label>10.1038/aps.2012.3  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Animals, Newborn<br/>Apoptosis--drug effects<br/>Behavior, Animal--drug effects<br/>Blotting, Western<br/>CA1 Region, Hippocampal--drug effects<br/>CA3 Region, Hippocampal--drug effects<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Centella--chemistry<br/>Cognition--drug effects<br/>Dementia--chemically induced<br/>Disease Models, Animal<br/>Dose-Response Relationship, Drug<br/>Flow Cytometry<br/>Glutathione--metabolism<br/>Heat-Shock Proteins--metabolism<br/>Humans<br/>Lipid Peroxidation--drug effects<br/>Membrane Potential, Mitochondrial--drug effects<br/>Memory--drug effects<br/>Mice<br/>Neuroblastoma--metabolism<br/>Neuroprotective Agents--isolation & purification<br/>Nootropic Agents--isolation & purification<br/>Oxidative Stress--drug effects<br/>Pentacyclic Triterpenes--isolation & purification<br/>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha<br/>Sirtuin 1--metabolism<br/>Sodium Glutamate<br/>Superoxide Dismutase--metabolism<br/>Time Factors<br/>Transcription Factors--metabolism