Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. [electronic resource]
- Neuroscience May 2012
- 308-32 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1873-7544
10.1016/j.neuroscience.2012.03.004 doi
Animals Apoptosis--drug effects Central Nervous System Stimulants--toxicity DNA Fragmentation Dopaminergic Neurons--drug effects Male Membrane Potential, Mitochondrial--drug effects Methamphetamine--toxicity Microscopy, Electron, Transmission Nerve Degeneration--chemically induced Proteasome Endopeptidase Complex Protein Kinase C-delta--metabolism RNA, Small Interfering Rats Rats, Wistar Signal Transduction--drug effects Transfection Ubiquitin-Protein Ligase Complexes--drug effects