TY  - GEN
AU  - Mladenova,Gabriela
AU  - Annedi,Subhash C
AU  - Ramnauth,Jailall
AU  - Maddaford,Shawn P
AU  - Rakhit,Suman
AU  - Andrews,John S
AU  - Zhang,Dongqin
AU  - Porreca,Frank
TI  - First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain
SN  - 1520-4804
PY  - 2012///0831
KW  - Adrenergic Uptake Inhibitors
KW  - chemical synthesis
KW  - Analgesics
KW  - Animals
KW  - CHO Cells
KW  - Coronary Vessels
KW  - drug effects
KW  - Cricetinae
KW  - Cricetulus
KW  - Cyclohexanes
KW  - ERG1 Potassium Channel
KW  - Ether-A-Go-Go Potassium Channels
KW  - antagonists & inhibitors
KW  - HEK293 Cells
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - In Vitro Techniques
KW  - Indoles
KW  - Muscle Contraction
KW  - Muscle, Smooth, Vascular
KW  - Neuralgia
KW  - drug therapy
KW  - Nitric Oxide Synthase Type I
KW  - Norepinephrine Plasma Membrane Transport Proteins
KW  - metabolism
KW  - Rats
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Thiophenes
KW  - Vascular Resistance
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm300138g
ER  -