Mladenova, Gabriela <br/><br/>
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.  [electronic resource] 

 -  Journal of medicinal chemistry  Apr 2012 
 - 3488-501 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm300138g  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adrenergic Uptake Inhibitors--chemical synthesis<br/>Analgesics--chemical synthesis<br/>Animals<br/>CHO Cells<br/>Coronary Vessels--drug effects<br/>Cricetinae<br/>Cricetulus<br/>Cyclohexanes--chemical synthesis<br/>ERG1 Potassium Channel<br/>Ether-A-Go-Go Potassium Channels--antagonists & inhibitors<br/>HEK293 Cells<br/>High-Throughput Screening Assays<br/>Humans<br/>In Vitro Techniques<br/>Indoles--chemical synthesis<br/>Muscle Contraction<br/>Muscle, Smooth, Vascular--drug effects<br/>Neuralgia--drug therapy<br/>Nitric Oxide Synthase Type I--antagonists & inhibitors<br/>Norepinephrine Plasma Membrane Transport Proteins--metabolism<br/>Rats<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Thiophenes--chemical synthesis<br/>Vascular Resistance