Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle. [electronic resource]
- Journal of molecular medicine (Berlin, Germany) Oct 2012
- 1145-60 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1432-1440
10.1007/s00109-012-0887-y doi
Animals Autophagy Blood Glucose Carnitine O-Palmitoyltransferase--metabolism Diabetes Mellitus, Experimental--blood Diet, High-Fat--adverse effects Electron Transport Electron Transport Chain Complex Proteins--metabolism Gene Expression Glucosylceramides--metabolism Insulin--physiology Insulin Resistance Lipid Metabolism Male Malondialdehyde--metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Mitochondria, Muscle--enzymology Mitochondrial Proteins--genetics Muscle, Skeletal--metabolism Obesity--blood Oxidative Stress Oxygen Consumption Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Signal Transduction Streptozocin Trans-Activators--genetics Transcription Factors