TY  - GEN
AU  - Krenzlin,Harald
AU  - Demuth,Ilja
AU  - Salewsky,Bastian
AU  - Wessendorf,Petra
AU  - Weidele,Kathrin
AU  - Bürkle,Alexander
AU  - Digweed,Martin
TI  - DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress
SN  - 1553-7404
PY  - 2012///0904
KW  - Animals
KW  - Bleomycin
KW  - pharmacology
KW  - Cell Cycle Proteins
KW  - genetics
KW  - Cells, Cultured
KW  - DNA Breaks, Double-Stranded
KW  - DNA Damage
KW  - drug effects
KW  - DNA-Binding Proteins
KW  - Gene Expression Regulation
KW  - Gene Knockdown Techniques
KW  - Humans
KW  - Mice
KW  - Mice, Mutant Strains
KW  - NAD
KW  - metabolism
KW  - Nijmegen Breakage Syndrome
KW  - Nuclear Proteins
KW  - Oxidative Stress
KW  - Poly (ADP-Ribose) Polymerase-1
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - Poly(ADP-ribose) Polymerases
KW  - Reactive Oxygen Species
KW  - Transcriptional Activation
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pgen.1002557
ER  -