Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. [electronic resource]
- The Journal of biological chemistry May 2012
- 15874-85 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M112.340588 doi
Antineoplastic Agents--pharmacology Blotting, Western Carcinoma, Hepatocellular--immunology Cell Line, Tumor Cell Survival--drug effects Cells, Cultured Chaperonin 60--immunology Coculture Techniques Cytotoxicity, Immunologic--immunology Dose-Response Relationship, Drug Exosomes--drug effects Granzymes--immunology HSP70 Heat-Shock Proteins--immunology HSP90 Heat-Shock Proteins--immunology Heat-Shock Proteins--immunology Hep G2 Cells Hot Temperature Humans K562 Cells Killer Cells, Natural--immunology Liver Neoplasms--immunology NK Cell Lectin-Like Receptor Subfamily D--immunology