The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. [electronic resource]
- Oncogene Jan 2013
- 471-8 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2012.66 doi
Animals Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic--genetics Colonic Neoplasms--enzymology Endopeptidases--genetics Genes, Tumor Suppressor HCT116 Cells HEK293 Cells Humans Male Mice Mice, Inbred BALB C Mice, Nude Nuclear Proteins--genetics Phosphoprotein Phosphatases--genetics Protein Binding Protein Interaction Domains and Motifs Protein Isoforms Proto-Oncogene Proteins c-akt--genetics Signal Transduction Ubiquitination Up-Regulation