TY - GEN AU - Zichel,Ran AU - Chearwae,Wanida AU - Pandey,Gouri Shankar AU - Golding,Basil AU - Sauna,Zuben E TI - Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins SN - 1932-6203 PY - 2012///0827 KW - Animals KW - Antibodies, Monoclonal KW - chemistry KW - Aptamers, Peptide KW - Biosensing Techniques KW - Cattle KW - Codon KW - Enzyme-Linked Immunosorbent Assay KW - methods KW - Epitopes KW - Humans KW - Interferometry KW - Kinetics KW - Protein Binding KW - Protein Conformation KW - Protein Processing, Post-Translational KW - Proteins KW - Sensitivity and Specificity KW - Substrate Specificity KW - Temperature KW - Thrombin N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0031948 ER -