Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. [electronic resource]
- The Journal of biological chemistry Apr 2012
- 14289-300 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M112.353201 doi
Chemistry, Pharmaceutical--methods Chromatin--metabolism Crystallography, X-Ray--methods DNA Replication--physiology Drug Design Flow Cytometry--methods Genes, Reporter HeLa Cells Humans Inhibitory Concentration 50 Ligands Microscopy, Fluorescence--methods Molecular Conformation Peptides--chemistry Phosphorylation Proliferating Cell Nuclear Antigen--metabolism Protein Interaction Mapping--methods Recombinant Proteins--chemistry