Punchihewa, Chandanamali

Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. [electronic resource] - The Journal of biological chemistry Apr 2012 - 14289-300 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.353201 doi


Chemistry, Pharmaceutical--methods
Chromatin--metabolism
Crystallography, X-Ray--methods
DNA Replication--physiology
Drug Design
Flow Cytometry--methods
Genes, Reporter
HeLa Cells
Humans
Inhibitory Concentration 50
Ligands
Microscopy, Fluorescence--methods
Molecular Conformation
Peptides--chemistry
Phosphorylation
Proliferating Cell Nuclear Antigen--metabolism
Protein Interaction Mapping--methods
Recombinant Proteins--chemistry