TY  - GEN
AU  - Tong,Gary
AU  - Wang,Jun-Sheng
AU  - Sverdlov,Oleksandr
AU  - Huang,Shu-Pang
AU  - Slemmon,Randy
AU  - Croop,Robert
AU  - Castaneda,Lorna
AU  - Gu,Huidong
AU  - Wong,Oi
AU  - Li,Hewei
AU  - Berman,Robert M
AU  - Smith,Christina
AU  - Albright,Charles F
AU  - Dockens,Randy C
TI  - Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers
SN  - 1879-114X
PY  - 2012///0716
KW  - Administration, Oral
KW  - Adolescent
KW  - Adult
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Amyloid beta-Peptides
KW  - blood
KW  - Basic Helix-Loop-Helix Transcription Factors
KW  - Biomarkers
KW  - analysis
KW  - Dose-Response Relationship, Drug
KW  - Dual Specificity Phosphatase 6
KW  - Homeodomain Proteins
KW  - Humans
KW  - Male
KW  - Oxadiazoles
KW  - administration & dosage
KW  - Peptide Fragments
KW  - Peptides
KW  - Sulfonamides
KW  - Transcription Factor HES-1
KW  - Trefoil Factor-3
KW  - Young Adult
N1  - Publication Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.clinthera.2012.01.022
ER  -