TY  - GEN
AU  - Yuan,W
AU  - Stawiski,E
AU  - Janakiraman,V
AU  - Chan,E
AU  - Durinck,S
AU  - Edgar,K A
AU  - Kljavin,N M
AU  - Rivers,C S
AU  - Gnad,F
AU  - Roose-Girma,M
AU  - Haverty,P M
AU  - Fedorowicz,G
AU  - Heldens,S
AU  - Soriano,R H
AU  - Zhang,Z
AU  - Wallin,J J
AU  - Johnson,L
AU  - Merchant,M
AU  - Modrusan,Z
AU  - Stern,H M
AU  - Seshagiri,S
TI  - Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
SN  - 1476-5594
PY  - 2013///0311
KW  - Adenocarcinoma
KW  - genetics
KW  - Alleles
KW  - Animals
KW  - Base Sequence
KW  - Class I Phosphatidylinositol 3-Kinases
KW  - Enzyme Activation
KW  - drug effects
KW  - Female
KW  - Gene Expression Regulation, Neoplastic
KW  - Gene Knock-In Techniques
KW  - Genomics
KW  - Humans
KW  - Mammary Neoplasms, Experimental
KW  - Mice
KW  - Mutation
KW  - Organ Specificity
KW  - Phosphatidylinositol 3-Kinases
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Protein Kinase Inhibitors
KW  - pharmacology
KW  - Tumor Suppressor Protein p53
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1038/onc.2012.53
ER  -