Improvement of replication fidelity by certain mesalazine derivatives. [electronic resource]
- International journal of oncology May 2012
- 1331-8 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1791-2423
10.3892/ijo.2012.1381 doi
Adaptor Proteins, Signal Transducing--genetics Anticarcinogenic Agents--pharmacology Ataxia Telangiectasia Mutated Proteins Cell Cycle Checkpoints--drug effects Cell Cycle Proteins--metabolism Cell Proliferation--drug effects Checkpoint Kinase 1 Colorectal Neoplasms--genetics DNA Replication--drug effects Dose-Response Relationship, Drug Free Radical Scavengers--pharmacology HCT116 Cells HT29 Cells Humans Mesalamine--pharmacology MutL Protein Homolog 1 Mutation Nuclear Proteins--genetics Oxidative Stress--drug effects Protein Kinases--metabolism Protein Serine-Threonine Kinases--metabolism Signal Transduction--drug effects Superoxides--metabolism Transfection Tumor Suppressor Protein p53--genetics