Zhang, Liwen <br/><br/>
An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.  [electronic resource] 

 -  International journal of biological sciences  2012 
 - 310-27 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1449-2288 
<br/><br/><label>Standard No.: </label>10.7150/ijbs.3524  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antibodies, Monoclonal--pharmacology<br/>Antibody Affinity<br/>Anticholesteremic Agents--administration & dosage<br/>Cells, Cultured--drug effects<br/>Cholesterol Ester Transfer Proteins--genetics<br/>Cholesterol, LDL--blood<br/>Gene Expression Profiling<br/>Gene Expression Regulation--drug effects<br/>Hep G2 Cells--drug effects<br/>Hepatocytes--drug effects<br/>Humans<br/>Immunization, Passive<br/>Lipid Metabolism--genetics<br/>Liver--drug effects<br/>Macaca mulatta<br/>Metabolic Syndrome--drug therapy<br/>Mice<br/>Mice, Transgenic<br/>Proprotein Convertase 9<br/>Proprotein Convertases--antagonists & inhibitors<br/>RNA, Messenger--metabolism<br/>Receptors, LDL--biosynthesis<br/>Recombinant Proteins--metabolism<br/>Serine Endopeptidases--biosynthesis<br/>Simvastatin--administration & dosage<br/>Sterol Regulatory Element Binding Proteins--physiology