Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. [electronic resource]
- Cancer research Apr 2012
- 1878-89 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1538-7445
10.1158/0008-5472.CAN-11-3132 doi
Animals CD24 Antigen--physiology Enzyme Activation Epithelial-Mesenchymal Transition Humans Hyaluronan Receptors--physiology Luminescent Measurements Male Mice Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors Mitogen-Activated Protein Kinases--physiology Neoplasm Metastasis Neoplastic Stem Cells--pathology PTEN Phosphohydrolase--physiology Prostatic Neoplasms--drug therapy TOR Serine-Threonine Kinases--antagonists & inhibitors ras Proteins--physiology