A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Feb 2012
- 3317-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1113761109 doi
Amino Acid Sequence Animals Binding Sites Blood-Brain Barrier Crystallography, X-Ray Disks Large Homolog 4 Protein Drug Design Drug Evaluation, Preclinical Guanylate Kinases--antagonists & inhibitors Humans Infarction, Middle Cerebral Artery--complications Intracellular Signaling Peptides and Proteins--antagonists & inhibitors Learning Disabilities--etiology Male Membrane Proteins--antagonists & inhibitors Mice Mice, Inbred C57BL Models, Molecular Molecular Sequence Data Molecular Targeted Therapy Movement Disorders--etiology Neuroprotective Agents--chemical synthesis Nuclear Magnetic Resonance, Biomolecular PDZ Domains--drug effects Peptides--chemical synthesis Postural Balance Protein Conformation Sensation Disorders--etiology